Product Code: SIT8384.0
CAS No: 13154-24-0
SDS Sheets: EU | US
Pack Size
25 g
100 g
750 g
2 kg
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16 kg
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160 kg
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Prices listed are EXW price (Morrisville, PA US) in USD. Prices vary depending on currency and Incoterms.

Product data and descriptions listed are typical values, not intended to be used as specification.

  • Einecs Number

  • Synonyms

  • HMIS

  • Molecular Formula

  • Molecular Weight (g/mol)

  • Purity (%)

  • TSCA

  • Autoignition Temp (˚C)

  • Boiling Point (˚C/mmHg)

  • Density (g/mL)

  • Flash Point (˚C)

    62 °C
  • Refractive Index @ 20˚C


Additional Properties

  • Hydrolytic Sensitivity

    8: reacts rapidly with moisture, water, protic solvents
  • Application

    Review of synthetic utility.1
    Review on organosilane protecting groups.2
    Employed in nucleotide synthesis.3
    Protection and stereocontrol of reaction of pyrroles.4
    Quantitatively converts O-acetyl-protected glycosylthiomethyl phosphonate esters to their phosphonates.5
    Used to form stable enol silyl ethers that can be oxidized to enones or ?-TIPS-enones.6
    Reacts with hydrazine to form the mono-TIPShydrazine, which can be converted to TIPS-protected hydrazones and further to unsymmetrical azines.7


    F&F: Vol. 5, p 75.


    1. Handbook of Reagents for Organic Synthesis, Reagents for Silicon-Mediated Organic Synthesis, Fuchs, P. L. Ed., John Wiley and Sons, Ltd., 2011, p. 554-558.
    2. Larson, G. L. “Silicon-Based Blocking Agents” Gelest, Inc. 2014.
    3. Ogilvie, K. et al. Tetrahedron Lett. 1974, 2861. Ogilvie, K. et al. Carbohyd., Nucleosides, Nucleotides 1976, 3, 197.
    4. Pattenden, G.; Robertson, G. M. Tetrahedron Lett. 1986, 27, 399.
    5. Zhu, X. et al. J. Org. Chem. 2004, 69, 6843.
    6. Yu, J.-Q. et al. Org. Lett. 2005, 7, 1415.
    7. Justo de Pomar, J. C.; Soderquist, J. A. Tetrahedron Lett. 2000, 41, 3285.


  • Packaging Under

  • Trialkylsilyl Blocking Agent

    Used as a protecting group for reactive hydrogens in alcohols, amines, thiols, and carboxylic acids. Organosilanes are hydrogen-like, can be introduced in high yield, and can be removed under selective conditions. They are stable over a wide range of reaction conditions and can be removed in the presence of other functional groups, including other protecting groups. The tolerance of silylated alcohols to chemical transformations summary is presented in Table 1 of the Silicon-Based Blocking Agents brochure.

    Triisopropylchlorosilane; Chlorotriisopropylsilane; TIPS-Cl

  • TIPS ethers more stable than TBS ethers
  • Protects carboxylic acids
  • Used in synthesis of free-4-hydroxylhexopyranoses
  • Steric bulk allows for selective silylation of compounds with more than one hydroxyl group
  • Summary of selective deprotection conditions is provided in Table 7 through Table 20 of the Silicon-Based Blocking Agents brochure