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Product Code: SIT7273.0

Cas No: 69304-37-6

R&D quantities:

25 g
5 g
750 g

Interested in a Commercial Order?

Boiling Point: 120° / 1.5

Molecular Weight: 315.43

Specific Gravity: 0.986

Flashpoint: 76°C (169°F)

HMIS Key: 3-2-1-X

Hydrolytic Sensitivity: 8: reacts rapidly with moisture, water, protic solvents

Formula: C12H28Cl2OSi2

Refractive Index: 1.4543

Application: Review of synthetic utility.1
Review on organosilane protecting groups.2
Reagent for protection of 3',5' hydroxy nucleosides.3,4
Key review in natural products synthesis.5
Protects the four equatorial hydroxyls of inositol in a single step.6

Reference: 1. Handbook of Reagents for Organic Synthesis, Reagents for Silicon-Mediated Organic Synthesis, Fuchs, P. L. Ed., John Wiley and Sons, Ltd., 2011, p. 230-233.
2. Larson, G. L. “Silicon-Based Blocking Agents” Gelest, Inc. 2014.
3. Kanaya, E. N. et al. Biochemistry 1987, 26, 7159.
4. Markiewicz, W. J. Chem. Res. 1979, 24.
5. Ziegler, T. et al. Trends Org. Chem. 1997, 6, 91.
6. Martin-Lomas, M. et al. Eur. J. Org. Chem. 2000, 1539.

Fieser: F&F: Vol. 16, p 125.