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- HMIS 3-2-1-X
- Molecular Formula C10H18F6O6S2Si
- Molecular Weight (g/mol) 440.46
- Purity (%) 95%
- Boiling Point (˚C/mmHg) 73-5° / .35
- Density (g/mL) 1.358
- Flash Point (˚C) 90°C (194°F)
- Refractive Index @ 20˚C 1.3975
Review of synthetic utility.1
Reagent for protection of diols.2
Used to doubly block sialic acid for use in efficient silylation reactions.3
Can protect diols and be regioselectively mono-deprotected.4
1. Handbook of Reagents for Organic Synthesis, Reagents for Silicon-Mediated Organic Synthesis, Fuchs, P. L. Ed., John Wiley and Sons, Ltd., 2011, p. 209-222.
2. Corey, E. J.; Hopkins, P. B. Tetrahedron Lett. 1982, 23, 4871.
3. Hanshima, S. Eur. J. Org. Chem. 2009, 4215.
4. Yu, M.; Pagenkopf, B. L. J. Org. Chem. 2002, 67, 4553.
Bridging Silicon-Based Blocking Agent
Used as a protecting group for reactive hydrogens in alcohols, amines, thiols, and carboxylic acids. Organosilanes are hydrogen-like, can be introduced in high yield, and can be removed under selective conditions. They are stable over a wide range of reaction conditions and can be removed in the presence of other functional groups, including other protecting groups. The tolerance of silylated alcohols to chemical transformations summary is presented in Table 1 of the Silicon-Based Blocking Agents brochure.
Di-tert-butylsilylbis(trifluoromethanesulfonate); Di-t-butylsilylbis(triflate); DTBS