85272-31-7

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DI-t-BUTYLSILYLBIS(TRIFLUOROMETHANESULFONATE)

Product Code: SID3345.0

Cas No: 85272-31-7

R&D quantities:

2.5 kg
$6,612.50
25 g
$286.00
5 g
$72.00
Bridging Silicon-Based Blocking Agent

Used as a protecting group for reactive hydrogens in alcohols, amines, thiols, and carboxylic acids. Organosilanes are hydrogen-like, can be introduced in high yield, and can be removed under selective conditions. They are stable over a wide range of reaction conditions and can be removed in the presence of other functional groups, including other protecting groups. The tolerance of silylated alcohols to chemical transformations summary is presented in Table 1 of the Silicon-Based Blocking Agents brochure.

Di-tert-butylsilylbis(trifluoromethanesulfonate); Di-t-butylsilylbis(triflate); DTBS
  • More reactive than SID3205.0
  • Converts 1,3-diols to cyclic protected 1,3-diols
  • Reacts with 1,3-diols in preference to 1,2-diols
  • Summary of selective deprotection conditions is provided in Table 7 through Table 20 of the Silicon-Based Blocking Agents brochure
  • Boiling Point: 73-5° / .35

    Molecular Weight: 440.46

    Specific Gravity: 1.358

    Flashpoint: 90°C (194°F)

    HMIS Key: 3-2-1-X

    Hydrolytic Sensitivity: 8: reacts rapidly with moisture, water, protic solvents

    Formula: C10H18F6O6S2Si

    Refractive Index: 1.3975

    Application: Review of synthetic utility.1
    Reagent for protection of diols.2
    Used to doubly block sialic acid for use in efficient silylation reactions.3
    Can protect diols and be regioselectively mono-deprotected.4

    Reference: 1. Handbook of Reagents for Organic Synthesis, Reagents for Silicon-Mediated Organic Synthesis, Fuchs, P. L. Ed., John Wiley and Sons, Ltd., 2011, p. 209-222.
    2. Corey, E. J.; Hopkins, P. B. Tetrahedron Lett. 1982, 23, 4871.
    3. Hanshima, S. Eur. J. Org. Chem. 2009, 4215.
    4. Yu, M.; Pagenkopf, B. L. J. Org. Chem. 2002, 67, 4553.