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Product Code: SID3537.0

Cas No: 7751-38-4

R&D quantities:

50 g
10 g
1 kg

Boiling Point: 64-5° / 25

Molecular Weight: 185.17

Specific Gravity: 1.026

Flashpoint: 43°C (109°F)

HMIS Key: 3-2-1-X

Hydrolytic Sensitivity: 8: reacts rapidly with moisture, water, protic solvents

Formula: C6H14Cl2Si

Refractive Index: 1.4450

Application: Review of synthetic utility.1
Forms bis(blocked) or tethered alcohols.2,3
Used as tether in ring-closing-metathesis (RCM) reaction.4
The bifunctional nature of the reagent allows for the templating of diverse groups in intermolecular reactions and ring formation.5

Reference: 1. Handbook of Reagents for Organic Synthesis, Reagents for Silicon-Mediated Organic Synthesis, Fuchs, P. L. Ed., John Wiley and Sons, Ltd., 2011, p. 222-228.
2. Bradford, C. et al. Tetrahedron Lett. 1995, 36, 4189.
3. Hutchinson, J. et al. Tetrahedron Lett. 1991, 32, 573.
4. Evans, P. A. et al. J. Am. Chem. Soc. 2003, 125, 14702.
5. Evans, P. A. et al. Angew. Chem., Int. Ed. Engl. 2003, 42, 1734.