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Product Code: SID3226.0

Cas No: 1314639-86-5

R&D quantities:

10 g

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Trialkylsilyl Blocking Agent

Used as a protecting group for reactive hydrogens in alcohols, amines, thiols, and carboxylic acids. Organosilanes are hydrogen-like, can be introduced in high yield, and can be removed under selective conditions. They are stable over a wide range of reaction conditions and can be removed in the presence of other functional groups, including other protecting groups. The tolerance of silylated alcohols to chemical transformations summary is presented in Table 1 of the Silicon-Based Blocking Agents brochure.

Di-tert-butylisobutylsilyltrifluoromethanesulfonate; Di-t-butylisobutylsilyltriflate; BIBS-OTf
  • Highly sterically-hindered blocking agent useful for protection of alcohols, amines, acids, enol silyl ethers
  • Summary of selective deprotection conditions is provided in Table 7 through Table 20 of the Silicon-Based Blocking Agents brochure
  • Boiling Point: 100-1° / 1

    Molecular Weight: 348.49


    Specific Gravity: 1.25

    HMIS Key: 3-1-1-X

    Hydrolytic Sensitivity: 7: reacts slowly with moisture/water

    Formula: C13H27F3O3SSi

    Application: Highly selective and very robust silicon-based protecting group capable of protecting alcohols, phenols, amines, carboxylic acids, and carbamates.1

    Reference: 1. Liang, H.; Hu. L.; Corey, E. J. Org. Lett. 2011, 13, 4120.