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Product Code: SIT8606.3

Cas No: 2975-46-4

25 g
Alkynylsilane Cross-Coupling Agent

The cross-coupling reaction is a highly useful methodology for the formation of carbon-carbon bonds. It involves two reagents, with one typically being a suitable organometallic reagent - the nucleophile - and the other a suitable organic substrate, normally an unsaturated halide, tosylate or similar - the electrophile.

3-Trimethylsilylpropynal; 3-Trimethylsilyl-2-propyn-1-al; 3-(Trimethylsilyl)propargyl aldehyde; Trimethylsilyl)acetylenecarboxaldehyde
  • Potential for the formation of alkynyl aldehydes
  • Used in the preparation of 1,3,5-triynes
  • Potential for the synthesis of 3-subsubstituted alkynals
  • Extensive review of silicon based cross-coupling agents: Denmark, S. E. et al. "Organic Reactions, Volume 75" Denmark, S. E. ed., John Wiley and Sons, 233, 2011
  • Specific Gravity: 0.862

    Flashpoint: 25°C (77°F)

    HMIS Key: 2-3-0-X

    Hydrolytic Sensitivity: 4: no reaction with water under neutral conditions

    Formula: C6H10OSi

    Refractive Index: 1.4432

    Application: Used in the preparation of 1,3,5-triynes.1

    Reference: 1. Mukai, C. et al. J. Org. Chem. 2001, 66, 5875.