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LITHIUM HEXAMETHYLDISILAZIDE, 0.85M in hexane (19-21 wt %)
Product data and descriptions listed are typical values, not intended to be used as specification.
Specific Gravity: 0.716
Flashpoint: -23°C (-9°F)
HMIS Key: 3-4-1-X
Hydrolytic Sensitivity: 7: reacts slowly with moisture/water
Application: Review of synthetic utility.1
Used in the use of chloroform in the trichloromethylation of a ketone in a scaled-up synthesis of ?-secretase inhibitor, spiropiperidine.2
Reference: 1. Handbook of Reagents for Organic Synthesis, Reagents for Silicon-Mediated Organic Synthesis, Fuchs, P. L. Ed., John Wiley and Sons, Ltd., 2011, p. 356-367.
2. Henegar, K. E. et al. Org. Process. Res. Dev. 2013, 17, 985.
Additional Properties: 19 - 21 wt %