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Product Code: SID3120.0

Cas No: 56310-18-0

2 kg
50 g
10 g
Trialkylsilyl Blocking Agent

Used as a protecting group for reactive hydrogens in alcohols, amines, thiols, and carboxylic acids. Organosilanes are hydrogen-like, can be introduced in high yield, and can be removed under selective conditions. They are stable over a wide range of reaction conditions and can be removed in the presence of other functional groups, including other protecting groups. The tolerance of silylated alcohols to chemical transformations summary is presented in Table 1 of the Silicon-Based Blocking Agents brochure.

Di-tert-butylchlorosilane; Chloro-bis(1,1-dimethylethyl)silyl hydride
  • Used in selective silylation of internal alcohols or diols
  • Summary of selective deprotection conditions is provided in Table 7 through Table 20 of the Silicon-Based Blocking Agents brochure
  • Specific Gravity: 0.884

    Flashpoint: 39°C (102°F)

    HMIS Key: 3-2-1-X

    Hydrolytic Sensitivity: 8: reacts rapidly with moisture, water, protic solvents

    Formula: C8H19ClSi

    Refractive Index: 1.4414

    Application: Review of synthetic utility.1
    Reagent for selective silylation of internal alcohols or diols.2
    Used as a stable reagent for linking two organic moieties.3

    Reference: 1. Handbook of Reagents for Organic Synthesis, Reagents for Silicon-Mediated Organic Synthesis, Fuchs, P. L. Ed., John Wiley and Sons, Ltd., 2011, p. 198-201.
    2. Tanino, K. et al. J. Org. Chem. 1998, 63, 2422.
    3. Gillard, J. W. et al. Tetrahedron Lett. 1991, 32, 1145.