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Product Code: SIC2285.0

Cas No: 1719-57-9

18 kg
2 kg
750 g
25 g
15 kg
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180 kg
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Product data and descriptions listed are typical values, not intended to be used as specification.

Specialty Silicon-Based Blocking Agent

Used as a protecting group for reactive hydrogens in alcohols, amines, thiols, and carboxylic acids. Organosilanes are hydrogen-like, can be introduced in high yield, and can be removed under selective conditions. They are stable over a wide range of reaction conditions and can be removed in the presence of other functional groups, including other protecting groups. The tolerance of silylated alcohols to chemical transformations summary is presented in Table 1 of the Silicon-Based Blocking Agents brochure.

Chloromethyldimethylchlorosilane; (Chlorodimethylsilyl)chloromethane; Chloro(chloromethyl)dimethylsilane; CMDMCS
  • Can form cyclic products with appropriate 1,2-difunctional substrates
  • Used in analytical applications for greater ECD detectability
  • Summary of selective deprotection conditions is provided in Table 7 through Table 20 of the Silicon-Based Blocking Agents brochure
  • EINECS Number: 217-006-6

    Alternative Name: CMDMCS

    Specific Gravity: 1.0865

    Flashpoint: 21°C (69°F)

    HMIS Key: 3-4-1-X

    Hydrolytic Sensitivity: 8: reacts rapidly with moisture, water, protic solvents

    Formula: C3H8Cl2Si


    Refractive Index: 1.4360

    Fieser: F&F: Vol. 16, p 71; Vol. 17, p 75; Vol. 21, p 129.

    Additional Properties: 355
    End-capper for silicones