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Product Code: SIB1938.0

Cas No: 29681-57-0

1.5 kg
25 g
5 g
Trialkylsilyl Blocking Agent

Used as a protecting group for reactive hydrogens in alcohols, amines, thiols, and carboxylic acids. Organosilanes are hydrogen-like, can be introduced in high yield, and can be removed under selective conditions. They are stable over a wide range of reaction conditions and can be removed in the presence of other functional groups, including other protecting groups. The tolerance of silylated alcohols to chemical transformations summary is presented in Table 1 of the Silicon-Based Blocking Agents brochure.

tert-Butyldimethylsilane; Dimethyl-t-butylsilane; tert-Butyl(dimethyl)silane; TBS-H
  • Sterically hindered organosilane capable of dehydrogenative coupling
  • Used for the protection of alcohols, amines, thiols, lactams, and carboxylic acids
  • Clean NMR characteristics of protecting group
  • Facile removal with flouride ion sources
  • Summary of selective deprotection conditions is provided in Table 7 through Table 20 of the Silicon-Based Blocking Agents brochure
  • Specific Gravity: 0.701

    Flashpoint: -11°C (12°F)

    HMIS Key: 2-4-1-X

    Hydrolytic Sensitivity: 3: reacts with aqueous base

    Formula: C6H16Si

    Refractive Index: 1.4005

    Application: Silylates phenols in presence of tris(pentafluorophenyl)borane.1
    Precursor for SiC thin films by supersonic jet epitaxy.2

    Reference: 1. Blackwell, J. M. et al. J. Org. Chem. 1999, 64, 4887.
    2. Boo, J. et al. Thin Solid Films 1998, 324, 124.


    Additional Properties: 290
    Silane reducing agent