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2-TRIMETHYLSILYLTHIAZOLE
Boiling Point: 51-3° / 10
Molecular Weight: 157.31
Alternative Name: DONDONI REAGENT
Specific Gravity: 0.986
Flashpoint: 62°C (144°F)
HMIS Key: 2-3-1-X
Hydrolytic Sensitivity: 7: reacts slowly with moisture/water
Formula: C6H11NSSi
Refractive Index: 1.498
Application: Review of synthetic utility.1
Convenient substitute for 2-lithiothiazole for introducing various substituents at C-2 of the thiazole ring.2
Reference: 1. Handbook of Reagents for Organic Synthesis, Reagents for Silicon-Mediated Organic Synthesis, Fuchs, P. L. Ed., John Wiley and Sons, Ltd., 2011, p. 712-719.
2. Dondoni, A. et al. J. Org. Chem. 1988, 53, 1748.
Fieser: F&F: Vol. 16, p 362.