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Alkynylsilane Cross-Coupling Agent
The cross-coupling reaction is a highly useful methodology for the formation of carbon-carbon bonds. It involves two reagents, with one typically being a suitable organometallic reagent - the nucleophile - and the other a suitable organic substrate, normally an unsaturated halide, tosylate or similar - the electrophile.
3-Trimethylsilylpropynoic acid; 2,2,-Dimethyl-2-silapentynoic acid; 3-(Trimethylsilyl)-2-propynoic acid
Boiling Point: 105-9° / 10
Melting Point: 47-9°
Molecular Weight: 142.23
Flashpoint: 96°C (205°F)
HMIS Key: 3-1-1-X
Hydrolytic Sensitivity: 4: no reaction with water under neutral conditions
Application: Potential for the preparation of propiolic acid derivatives.1
Reference: 1. Larson, G. L. “Silicon-Based Cross-Coupling Reagents” Gelest, Inc. 2011.