76513-69-4

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2-(TRIMETHYLSILYL)ETHOXYMETHYL CHLORIDE, 95%

Product Code: SIT8588.5

Cas No: 76513-69-4

R&D quantities:

25gm
$506.00
5gm
$127.00

Boiling Point: 57-9° / 8

EINECS Number: 278-483-4

Molecular Weight: 166.72

Alternative Name: SEM-CHLORIDE

Specific Gravity: 0.942

Flashpoint: 46°C (115°F)

HMIS Key: 4-3-1-X

Hydrolytic Sensitivity: 7: reacts slowly with moisture/water

Formula: C6H15ClOSi

Purity: 95%

Refractive Index: 1.4350

Application: Review of synthetic utility.1
Hydroxyl group protection reagent, cleaved with fluoride.2
Useful in the introduction of a protected hydroxymethyl moiety.3

Reference: 1. Handbook of Reagents for Organic Synthesis, Reagents for Silicon-Mediated Organic Synthesis, Fuchs, P. L. Ed., John Wiley and Sons, Ltd., 2011, p. 628-632.
2. Lipshutz, B. et al. Tetrahedron Lett. 1980, 21, 3343.
3. Eichelberger, U. et al. Tetrahedron 2002, 58, 545.

Fieser: F&F: Vol. 10, p 431; Vol. 15, p 344; Vol. 16, p 361.

Additional Properties: Stabilized with iPr2MeN