N-METHYL-N-TRIMETHYLSILYLTRIFLUOROACETAMIDE, 95%

Product Code: SIM6576.0
CAS No: 24589-78-4
SDS Sheets: EU | US
Pack Size
Quantity
Price
 
25 g
$119.00
100 g
$388.00
2 kg
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18 kg
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Product data and descriptions listed are typical values, not intended to be used as specification.

  • Einecs Number

    246-331-6
  • Synonyms

    MSTFA
  • HMIS

    3-4-1-X
  • Molecular Formula

    C6H12F3NOSi
  • Molecular Weight (g/mol)

    199.25
  • Purity (%)

    95%
  • TSCA

    Yes
  • Boiling Point (˚C/mmHg)

    131-132
  • Density (g/mL)

    1.074
  • Flash Point (˚C)

    26 °C
  • Refractive Index @ 20˚C

    1.3800

Additional Properties

  • Hydrolytic Sensitivity

    7: reacts slowly with moisture/water
  • Application

    Silylation reagent with volatile byproducts.1

    Reference

    1. Donike, M. J. Chromatogr. 1969, 42, 103.

    Safety

  • Hazard Info

    ipr mouse, LDLo, 1,000 mg/kg
  • Packaging Under

    Nitrogen
  • Trimethylsilyl Blocking Agent

    Used as a protecting group for reactive hydrogens in alcohols, amines, thiols, and carboxylic acids. Organosilanes are hydrogen-like, can be introduced in high yield, and can be removed under selective conditions. They are stable over a wide range of reaction conditions and can be removed in the presence of other functional groups, including other protecting groups. The tolerance of silylated alcohols to chemical transformations summary is presented in Table 1 of the Silicon-Based Blocking Agents brochure.

    N-Methyl-N-trimethylsilyltrifluoroacetamide; MSTFA; 2,2,2-Trifluoro-N-methyl-N-(trimethylsilyl) acetamide

  • Silylation reagent similar to SIB1846.0, but with liquid, volatile byproduct
  • Nafion SAC-13 has been shown to be a recyclable catalyst for the trimethylsilylation of primary, secondary, and tertiary alcohols in excellent yields and short reaction times
  • Summary of selective deprotection conditions is provided in Table 7 through Table 20 of the Silicon-Based Blocking Agents brochure