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Product Code: SIM6492.55

Cas No: 35692-27-4

5 g
Arylsilane Cross-Coupling Agent

The cross-coupling reaction is a highly useful methodology for the formation of carbon-carbon bonds. It involves two reagents, with one typically being a suitable organometallic reagent - the nucleophile - and the other a suitable organic substrate, normally an unsaturated halide, tosylate or similar - the electrophile.

p-Methoxyphenyltrimethoxysilane; 4-Trimethoxysilylanisole; (p-Anisyl)trimethoxysilane; 4-(Trimethoxysilyl)anisole; 1-Trimethoxysilyl-4-methoxybenzene; 1-Methoxy-4-(trimethoxysilyl)benzene
  • Couples with heterocyclic amines
  • Undergoes asymmetric coupling with α-bromoesters
  • Extensive review of silicon based cross-coupling agents: Denmark, S. E. et al. "Organic Reactions, Volume 75" Denmark, S. E. ed., John Wiley and Sons, 233, 2011
  • Specific Gravity: 1.094

    HMIS Key: 3-2-1-X

    Hydrolytic Sensitivity: 7: reacts slowly with moisture/water

    Formula: C10H16O4Si

    Refractive Index: 1.4868