1-(4-METHOXYPHENYL)-1-CHLOROSILACYCLOBUTANE

Product Code: SIM6492.3
CAS No: 251453-07-3
Pack Size
Quantity
Price
 
2.5 g
$225.00

Prices listed are EXW price (Morrisville, PA US) in USD. Prices vary depending on currency and Incoterms.

Product data and descriptions listed are typical values, not intended to be used as specification.

  • HMIS

    3-2-1-X
  • Molecular Formula

    C10H13ClOSi
  • Molecular Weight (g/mol)

    212.74
  • Boiling Point (˚C/mmHg)

    100/0.1
  • Density (g/mL)

    1.12
  • Refractive Index @ 20˚C

    1.528

Additional Properties

  • Hydrolytic Sensitivity

    8: reacts rapidly with moisture, water, protic solvents
  • Safety

  • Packaging Under

    Nitrogen
  • Arylsilane Cross-Coupling Agent

    The cross-coupling reaction is a highly useful methodology for the formation of carbon-carbon bonds. It involves two reagents, with one typically being a suitable organometallic reagent - the nucleophile - and the other a suitable organic substrate, normally an unsaturated halide, tosylate or similar - the electrophile.

    1-(4-Methoxyphenyl)-1-chlorosilacyclobutane

  • Example of aryl-substituted silacyclobutane useful for the transfer of an aryl group in cross-coupling applications
  • Underoes Pd-catalyzed cross-coupling with activated aromatic iodides
  • Extensive review of silicon based cross-coupling agents: Denmark, S. E. et al. "Organic Reactions, Volume 75" Denmark, S. E. ed., John Wiley and Sons, 233, 2011
  • Silicon Chemistry, Articles

    Silicon-Based Formation of Carbon-Carbon Bonds – Larson

    Hatanaka and Hiyama first reported the palladium-catalyzed, fluoride-promoted reaction of aryl, alkenyl, allyl, and ethynyltrimethylsilanes with aryl, vinil and allyl halides to form the respective cross-coupled products