1-(4-METHOXYPHENYL)-1-CHLOROSILACYCLOBUTANE

Product Code: SIM6492.3
CAS No: 251453-07-3
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251453-07-3
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Quantity
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2.5 g
$225.00

Product data and descriptions listed are typical values, not intended to be used as specification.

  • HMIS

    3-2-1-X
  • Molecular Formula

    C10H13ClOSi
  • Molecular Weight (g/mol)

    212.74
  • Boiling Point (˚C/mmHg)

    100° / 0.1
  • Density (g/mL)

    1.12
  • Refractive Index @ 20˚C

    1.528

Additional Properties

  • Hydrolytic Sensitivity

    8: reacts rapidly with moisture, water, protic solvents

    • Safety

  • Packaging Under

    Nitrogen

    • Arylsilane Cross-Coupling Agent

    The cross-coupling reaction is a highly useful methodology for the formation of carbon-carbon bonds. It involves two reagents, with one typically being a suitable organometallic reagent - the nucleophile - and the other a suitable organic substrate, normally an unsaturated halide, tosylate or similar - the electrophile.

    1-(4-Methoxyphenyl)-1-chlorosilacyclobutane

  • Example of aryl-substituted silacyclobutane useful for the transfer of an aryl group in cross-coupling applications
  • Underoes Pd-catalyzed cross-coupling with activated aromatic iodides
  • Extensive review of silicon based cross-coupling agents: Denmark, S. E. et al. "Organic Reactions, Volume 75" Denmark, S. E. ed., John Wiley and Sons, 233, 2011

    • Silicon Chemistry, Articles

    Silicon-Based Formation of Carbon-Carbon Bonds – Larson

    Hatanaka and Hiyama first reported the palladium-catalyzed, fluoride-promoted reaction of aryl, alkenyl, allyl, and ethynyltrimethylsilanes with aryl, vinil and allyl halides to form the respective cross-coupled products