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Alkynylsilane Cross-Coupling Agent
The cross-coupling reaction is a highly useful methodology for the formation of carbon-carbon bonds. It involves two reagents, with one typically being a suitable organometallic reagent - the nucleophile - and the other a suitable organic substrate, normally an unsaturated halide, tosylate or similar - the electrophile.
1-Heptynyltrimethylsilane; 1-(Trimethylsilyl)-1-heptyne; 1-Heptynyltrimethylsilane
Flashpoint: 42°C (108°F)
HMIS Key: 2-2-1-X
Hydrolytic Sensitivity: 4: no reaction with water under neutral conditions
Refractive Index: 1.4344
Application: Useful in silicon-mediated Sonogashira cross-coupling reactions.1
Reference: 1. Larson, G. L. “Silicon-Based Cross-Coupling Reagents” Gelest, Inc. 2011.