18419-84-6

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1,2-DIETHOXYTETRAMETHYLDISILANE     

Product Code: SID3395.2

Cas No: 18419-84-6

R&D quantities:

1 g
$132.00

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Silane Cross-Coupling Agent

The cross-coupling reaction is a highly useful methodology for the formation of carbon-carbon bonds. It involves two reagents, with one typically being a suitable organometallic reagent - the nucleophile - and the other a suitable organic substrate, normally an unsaturated halide, tosylate or similar - the electrophile.

1,2-Diethoxytetramethyldisilane; Tetramethyldiethoxydisilane; 1,2-Diethoxy-1,1,2,2-tetramethyldisilane
  • Useful for the preparation of aryl- and vinylsilanols
  • Used to convert aryl bromides to aryldimethylsilanols useful for cross-coupling protocols
  • Extensive review of silicon based cross-coupling agents: Denmark, S. E. et al. "Organic Reactions, Volume 75" Denmark, S. E. ed., John Wiley and Sons, 233, 2011

    • Boiling Point: 85-9° / 50

    Molecular Weight: 206.43

    Specific Gravity: 0.8499

    Flashpoint: 42°C (108°F)

    HMIS Key: 2-3-1-X

    Hydrolytic Sensitivity: 7: reacts slowly with moisture/water

    Formula: C8H22O2Si2

    Refractive Index: 1.423

    Application: Used to convert aryl bromides to aryldimethylsilanols useful for cross-coupling protocols.1

    Reference: 1. Denmark, S. E.; Kallemeyn, J. M. Org. Lett. 2003, 5, 3483.

    Additional Properties: Cross-coupling reagent