1,2-DIETHOXYTETRAMETHYLDISILANE

Product Code: SID3395.2
CAS No: 18419-84-6
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18419-84-6
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1 g
$159.00

Product data and descriptions listed are typical values, not intended to be used as specification.

  • Synonyms

    1,2-DIETHOXYTETRAMETHYLDISILANE
  • HMIS

    2-3-1-X
  • Molecular Formula

    C8H22O2Si2
  • Molecular Weight (g/mol)

    206.43
  • Purity (%)

    95%
  • TSCA

    No
  • Boiling Point (˚C/mmHg)

    85-9° / 50
  • Density (g/mL)

    0.8499
  • Flash Point (˚C)

    42 °C
  • Refractive Index @ 20˚C

    1.423

Additional Properties

  • Hydrolytic Sensitivity

    7: reacts slowly with moisture/water

    • Application

    Used to convert aryl bromides to aryldimethylsilanols useful for cross-coupling protocols.1

    Reference

    1. Denmark, S. E.; Kallemeyn, J. M. Org. Lett. 2003, 5, 3483.

    Safety

  • Packaging Under

    Nitrogen

    • Silane Cross-Coupling Agent

    The cross-coupling reaction is a highly useful methodology for the formation of carbon-carbon bonds. It involves two reagents, with one typically being a suitable organometallic reagent - the nucleophile - and the other a suitable organic substrate, normally an unsaturated halide, tosylate or similar - the electrophile.

    1,2-Diethoxytetramethyldisilane; Tetramethyldiethoxydisilane; 1,2-Diethoxy-1,1,2,2-tetramethyldisilane

  • Useful for the preparation of aryl- and vinylsilanols
  • Used to convert aryl bromides to aryldimethylsilanols useful for cross-coupling protocols
  • Extensive review of silicon based cross-coupling agents: Denmark, S. E. et al. "Organic Reactions, Volume 75" Denmark, S. E. ed., John Wiley and Sons, 233, 2011

    • Silicon Chemistry, Articles

    Silicon-Based Formation of Carbon-Carbon Bonds – Larson

    Hatanaka and Hiyama first reported the palladium-catalyzed, fluoride-promoted reaction of aryl, alkenyl, allyl, and ethynyltrimethylsilanes with aryl, vinil and allyl halides to form the respective cross-coupled products