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- Synonyms 1,2-DIETHOXYTETRAMETHYLDISILANE
- HMIS 2-3-1-X
- Molecular Formula C8H22O2Si2
- Molecular Weight (g/mol) 206.43
- Boiling Point (˚C/mmHg) 85-9° / 50
- Density (g/mL) 0.8499
- Flash Point (˚C) 42°C (108°F)
- Refractive Index @ 20˚C 1.423
Additional Properties
Application
Used to convert aryl bromides to aryldimethylsilanols useful for cross-coupling protocols.1
Reference
1. Denmark, S. E.; Kallemeyn, J. M. Org. Lett. 2003, 5, 3483.
Safety
Silane Cross-Coupling Agent
The cross-coupling reaction is a highly useful methodology for the formation of carbon-carbon bonds. It involves two reagents, with one typically being a suitable organometallic reagent - the nucleophile - and the other a suitable organic substrate, normally an unsaturated halide, tosylate or similar - the electrophile.
1,2-Diethoxytetramethyldisilane; Tetramethyldiethoxydisilane; 1,2-Diethoxy-1,1,2,2-tetramethyldisilane
Silicon Chemistry, Articles
Silicon-Based Formation of Carbon-Carbon Bonds – Larson
Hatanaka and Hiyama first reported the palladium-catalyzed, fluoride-promoted reaction of aryl, alkenyl, allyl, and ethynyltrimethylsilanes with aryl, vinil and allyl halides to form the respective cross-coupled products
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