CYCLOTRIMETHYLENEMETHYLCHLOROSILANE

Product Code: SIC2572.0
CAS No: 2351-34-0
SDS Sheets: EU | US
Pack Size
Quantity
Price
 
750 g
$12,075.00
5 g
$182.00

Product data and descriptions listed are typical values, not intended to be used as specification.

  • HMIS

    3-4-1-X
  • Molecular Formula

    C4H9ClSi
  • Molecular Weight (g/mol)

    120.66
  • TSCA

    No
  • Boiling Point (˚C/mmHg)

    103°
  • Density (g/mL)

    0.985
  • Flash Point (˚C)

    2°C (36°F)
  • Refractive Index @ 20˚C

    1.4500

Additional Properties

  • Hydrolytic Sensitivity

    8: reacts rapidly with moisture, water, protic solvents
  • Application

    Review of synthetic utility.1
    !ntermediate for enoxysilacyclobutanes.2
    Precursor to various aryl and alkenylsilacyclobutanes suitable as a nucleophile in silicon-based cross-coupling.3

    Reference

    1. Handbook of Reagents for Organic Synthesis, Reagents for Silicon-Mediated Organic Synthesis, Fuchs, P. L. Ed., John Wiley and Sons, Ltd., 2011, p. 166-170.
    2. Denmark, S. et al. J. Am. Chem. Soc. 1994, 116, 7026.
    3. Denmark, S. E.; Sweis, R. F. Acc. Chem. Res. 2002, 35, 835.

    Safety

  • Packaging Under

    Nitrogen
  • Silane Cross-Coupling Agent

    The cross-coupling reaction is a highly useful methodology for the formation of carbon-carbon bonds. It involves two reagents, with one typically being a suitable organometallic reagent - the nucleophile - and the other a suitable organic substrate, normally an unsaturated halide, tosylate or similar - the electrophile.

    Cyclotrimethylenemethylchlorosilane; 1-Chloro-1-methylsilacyclobutane

  • !ntermediate for enoxysilacyclobutanes
  • Precursor to various aryl and alkenylsilacyclobutanes suitable as a nucleophile in silicon-based cross-coupling
  • Precursor for aryl- and vinyl-substituted silacyclobutanes useful for aryl cross-coupling reactions
  • Extensive review of silicon based cross-coupling agents: Denmark, S. E. et al. "Organic Reactions, Volume 75" Denmark, S. E. ed., John Wiley and Sons, 233, 2011
  • Silicon Chemistry, Articles

    Silicon-Based Formation of Carbon-Carbon Bonds – Larson

    Hatanaka and Hiyama first reported the palladium-catalyzed, fluoride-promoted reaction of aryl, alkenyl, allyl, and ethynyltrimethylsilanes with aryl, vinil and allyl halides to form the respective cross-coupled products