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t-BUTYLDIMETHYLCHLOROSILANE, 1.0M in methylene chloride

Product Code: SIB1935.2

Cas No: 18162-48-6

2.5 kg
100 g
Trialkylsilyl Blocking Agent

Used as a protecting group for reactive hydrogens in alcohols, amines, thiols, and carboxylic acids. Organosilanes are hydrogen-like, can be introduced in high yield, and can be removed under selective conditions. They are stable over a wide range of reaction conditions and can be removed in the presence of other functional groups, including other protecting groups. The tolerance of silylated alcohols to chemical transformations summary is presented in Table 1 of the Silicon-Based Blocking Agents brochure.

tert-Butyldimethylchlorosilane; TBS-Cl; Chlorodimethyl-t-butylsilane; tert-Butylchlorodimethylsilane; Chloro(1,1-dimethylethyl)dimethylsilane
  • Excellent for 1° and 2° alcohols
  • Silylation catalyzed by imidazole
  • Stable to many reagents
  • Can be selectively cleaved in presence of acetate, THP and benzyl ethers among others
  • Used for the protection of alcohols, amines, thiols, lactams, and carboxylic acids
  • Clean NMR characteristics of protecting group
  • Facile removal with flouride ion sources
  • Summary of selective deprotection conditions is provided in Table 7 through Table 20 of the Silicon-Based Blocking Agents brochure
  • EINECS Number: 242-042-4

    Specific Gravity: 1.225

    Flashpoint: 57°C (136°F)

    HMIS Key: 3-2-1-X

    Hydrolytic Sensitivity: 7: reacts slowly with moisture/water

    Formula: C6H15ClSi