BROMOMETHYLDIMETHYLCHLOROSILANE

Product Code: SIB1890.0
CAS No: 16532-02-8
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16532-02-8
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Quantity
Price
 
25 g
$106.00
100 g
$344.00

Product data and descriptions listed are typical values, not intended to be used as specification.

  • Einecs Number

    240-601-7
  • HMIS

    3-2-1-X
  • Molecular Formula

    C3H8BrClSi
  • Molecular Weight (g/mol)

    187.54
  • Purity (%)

    97%
  • TSCA

    Yes
  • Boiling Point (˚C/mmHg)

    130-1°
  • Density (g/mL)

    1.375
  • Flash Point (˚C)

    41 °C
  • Refractive Index @ 20˚C

    1.4650

Additional Properties

  • Hydrolytic Sensitivity

    8: reacts rapidly with moisture, water, protic solvents

    • Application

    Review of synthetic utility.1
    Modifies ITO electrodes allowing bonding of polyvinylpyridine.2
    Forms oxasilacycles via a silylation/free-radical addition sequence. The resulting oxasilacycles can be oxidized and desilylated to diols.3
    Used in a silicon-based templated cyclization to produce 1,4 diols.4,5

    Reference

    1. Handbook of Reagents for Organic Synthesis, Reagents for Silicon-Mediated Organic Synthesis, Fuchs, P. L. Ed., John Wiley and Sons, Ltd., 2011, p. 85-92.
    2. Privman, M. et al. J. Am. Chem. Soc. 2009, 131, 1314.
    3. Newlander, K. A. et al. J. Org. Chem. 1997, 62, 6726.
    4. Stork, G.; Kahn, M. J. Am. Chem. Soc. 1985, 107, 500.
    5. Lejeune, J.; Lallemand, J. Y. Tetrahedron Lett. 1992, 33, 2977.

    Safety

  • Packaging Under

    Nitrogen

    • Specialty Silicon-Based Blocking Agent

    Used as a protecting group for reactive hydrogens in alcohols, amines, thiols, and carboxylic acids. Organosilanes are hydrogen-like, can be introduced in high yield, and can be removed under selective conditions. They are stable over a wide range of reaction conditions and can be removed in the presence of other functional groups, including other protecting groups. The tolerance of silylated alcohols to chemical transformations summary is presented in Table 1 of the Silicon-Based Blocking Agents brochure.

    Bromomethyldimethylchlorosilane; Dimethylchlorosilylbromomethane

  • Has been applied to the synthesis of diols and β-methyl alcohols
  • Summary of selective deprotection conditions is provided in Table 7 through Table 20 of the Silicon-Based Blocking Agents brochure