N,N'-BIS(TRIMETHYLSILYL)UREA

Product Code: SIB1878.0
CAS No: 18297-63-7
SDS Sheets: EU | US
COMMERCIAL
18297-63-7
Pack Size
Quantity
Price
 
50 g
$22.00
250 g
$83.00
10 kg
$910.00
100 kg
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Product data and descriptions listed are typical values, not intended to be used as specification.

  • Einecs Number

    242-177-9
  • Synonyms

    BSU
  • HMIS

    2-2-1-X
  • Molecular Formula

    C7H20N2OSi2
  • Molecular Weight (g/mol)

    204.42
  • TSCA

    Yes
  • Melting Point (˚C)

    222-4°

Additional Properties

  • Hydrolytic Sensitivity

    7: reacts slowly with moisture/water
  • Application

    Review on organosilane protecting groups.1

    Fieser

    F&F: Vol. 16, p 82.

    Reference

    1. Larson, G. L. “Silicon-Based Blocking Agents” Gelest, Inc. 2014.

    Safety

  • Packaging Under

    Nitrogen
  • Trimethylsilyl Blocking Agent

    Used as a protecting group for reactive hydrogens in alcohols, amines, thiols, and carboxylic acids. Organosilanes are hydrogen-like, can be introduced in high yield, and can be removed under selective conditions. They are stable over a wide range of reaction conditions and can be removed in the presence of other functional groups, including other protecting groups. The tolerance of silylated alcohols to chemical transformations summary is presented in Table 1 of the Silicon-Based Blocking Agents brochure.

    Bis(Trimethylsilyl)urea; 1,3-Bis(trimethylsilyl)urea; BSU

  • By-product is urea
  • Used for alcohols and acids
  • Used in synthesis of penicillins and cephalosporins
  • Nafion SAC-13 has been shown to be a recyclable catalyst for the trimethylsilylation of primary, secondary, and tertiary alcohols in excellent yields and short reaction times
  • Summary of selective deprotection conditions is provided in Table 7 through Table 20 of the Silicon-Based Blocking Agents brochure