BIS(TRIMETHYLSILYLMETHYL)AMINE

Hydrolytic Sensitivity

4: no reaction with water under neutral conditions

Opens epoxides with high regioselectivity.¹
Forms imine with formaldehyde that does not readily trimerize.^{2 This aldimine can be used to form ?-lactams.3,4
Reacts with ketones for form imines with (E)-isomer selectivity.5}

1. Constantieux, T. et al. Synlett 1998, 510.
2. Capperucci, A. et al. J. Organomet. Chem. 1993, 458, C1.
3. Palomo, C. et al. Ang. Chem., Int. Ed. Engl. 1996, 35, 1239.
4. Palomo, C. et al. J. Chem. Soc., Chem. Commun. 1997, 233.
5. Palomo, C. et al. J. Org. Chem. 1997, 62, 2070.

Packaging Under

Nitrogen