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Product Code: SIA0575.0

Cas No: 18752-21-1

2.5 g

Product data and descriptions listed are typical values, not intended to be used as specification.

Phenyl-Containing Blocking Agent

Used as a protecting group for reactive hydrogens in alcohols, amines, thiols, and carboxylic acids. Organosilanes are hydrogen-like, can be introduced in high yield, and can be removed under selective conditions. They are stable over a wide range of reaction conditions and can be removed in the presence of other functional groups, including other protecting groups. The tolerance of silylated alcohols to chemical transformations summary is presented in Table 1 of the Silicon-Based Blocking Agents brochure.

Allyltriphenylsilane; Propenyltriphenylsilane; 3-Triphenylsilylpropene
  • Reaction with triflic acid and then pyridine gives triphenylsilylpyridinium triflate, an active triphenylsilylating agent
  • Summary of selective deprotection conditions is provided in Table 7 through Table 20 of the Silicon-Based Blocking Agents brochure
  • HMIS Key: 2-1-0-X

    Hydrolytic Sensitivity: 2: reacts with aqueous acid

    Formula: C21H20Si

    TSCA: No

    Application: Provides stereoselective synthesis of dienes.1

    Reference: 1. Ikeda, Y. et al. Bull. Chem. Soc. Jpn. 1986, 59, 657.