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Product Code: SIA0535.0

Cas No: 24400-84-8

5 g
Trialkylsilyl Blocking Agent

Used as a protecting group for reactive hydrogens in alcohols, amines, thiols, and carboxylic acids. Organosilanes are hydrogen-like, can be introduced in high yield, and can be removed under selective conditions. They are stable over a wide range of reaction conditions and can be removed in the presence of other functional groups, including other protecting groups. The tolerance of silylated alcohols to chemical transformations summary is presented in Table 1 of the Silicon-Based Blocking Agents brochure.

Allyltriisopropylsilane; Propenyltriisopropylsilane; 3-Triisopropylsilylpropene
  • Reaction with triflic acid and then pyridine gives the active triisopropylsilylating agent, triisopropylsilylpyridinium triflate
  • Summary of selective deprotection conditions is provided in Table 7 through Table 20 of the Silicon-Based Blocking Agents brochure
  • Specific Gravity: 0.824

    Flashpoint: 76°C (169°F)

    HMIS Key: 2-2-0-X

    Hydrolytic Sensitivity: 4: no reaction with water under neutral conditions

    Formula: C12H26Si

    Refractive Index: 1.4670

    Application: Alkylated by primary alkyl bromides with greater regiospecificity than allyltrimethylsilane.1

    Reference: 1. Muchowski, J. et al. Tetrahedron Lett. 1985, 26, 5375.