The use of organosilanes to replace and thus protect groups with active hydrogens, primarily alcohols, amines, thiols, and carboxylic acids, has been employed in synthetic strategies for many years.

Key advantages behind the use of organosilanes for the protection of functional organic groups are the ability of being able to add and remove the silyl protecting group in high yields. One can chose from a extensive variety of silicon-based protecting groups to fit one’s needs. The differences in the various protecting groups are based on both electronic and steric factors with steric factors being the more often employed. Significantly, synthetic chemists are now able to selectively remove one silyl protecting group in the presence of another, second silyl protecting group. Difunctional silyl protecting groups are excellent in applications where diols are to be protected, thus offering a superior alternative to previous acetonide protection protocols.

Mono-functional Organosilane Blocking Agents

SIH6110.0

1,1,1,3,3,3-HEXAMETHYLDISILAZANE, 98%

SIP6728.0

PHENYLDIMETHYLCHLOROSILANE

SIB1935.0

t-BUTYLDIMETHYLCHLOROSILANE

SIT8250.0

TRIETHYLCHLOROSILANE

SIB1933.55

3-n-BUTYL-1,1-DIETHYL-1,3-DIHYDROBENZO[1,2]OXAZOLE

SIT7906.0

THEXYLDIMETHYLCHLOROSILANE

SIB1968.0

t-BUTYLDIPHENYLCHLOROSILANE

SIT8384.0

TRIISOPROPYLCHLOROSILANE

SIB1876.0

N,O-BIS(TRIMETHYLSILYL)TRIFLUOROACETAMIDE

SIB1846.0

N,O-BIS(TRIMETHYLSILYL)ACETAMIDE

SIB1938.0

t-BUTYLDIMETHYLSILANE

SIP6729.0

PHENYLDIMETHYLSILANE

SIT8330.0

TRIETHYLSILANE, 98%

Di-functional Organosilane Blocking Agents

SIB1072.0

BIS(DIMETHYLAMINO)DIMETHYLSILANE

SID4510.1

DIPHENYLDICHLOROSILANE, 99%

SID3402.0

DIETHYLDICHLOROSILANE

SID3537.0

DIISOPROPYLDICHLOROSILANE

SID3205.0

DI-t-BUTYLDICHLOROSILANE

SIB1042.0

1,2-BIS(CHLORODIMETHYLSILYL)ETHANE

SIT7273.0

1,1,3,3-TETRAISOPROPYL-1,3-DICHLORODISILOXANE

SID3345.0

DI-t-BUTYLSILYLBIS(TRIFLUOROMETHANESULFONATE)

Specialty Organosilane Blocking Agents

SIP6716.1

PENTAFLUOROPHENYLDIMETHYLCHLOROSILANE

SIT8589.2

2-(TRIMETHYLSILYL)ETHANOL

SIB1837.0

BIS(TRIMETHYLSILOXY)DICHLOROSILANE

SIT8588.5

2-(TRIMETHYLSILYL)ETHOXYMETHYL CHLORIDE, 95%

SIH5840.4

(HEPTADECAFLUORO-1,1,2,2-TETRAHYDRODECYL)DIMETHYLCHLOROSILANE

SIB1815.5

BIS((TRIDECAFLUORO-1,1,2,2-TETRAHYDROOCTYL)DIMETHYLSILOXY)METHYLCHLOROSILANE

SID3226.0

DI-t-BUTYLISOBUTYLSILYL TRIFLUOROMETHANESULFONATE

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