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Synthetic Organic Chemistry
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Silicon-Based Synthetic Reagents
Gelest produces a large variety of Silicon-based synthetic agents, which are used for the selective transformation of functional groups in organic synthesis. These reagents include those for Peterson olefinations, cyanosilylations, allylations, vinylations, cross-coupling reactions, silyl enol ethers for cross Aldol chemistry and electrophilic substitution of aldehydes and ketones, silyl ketene acetals for the electrophilic substitution of esters, various silanes for selective reductions (see the Gelest brochure, Silicon-Based Reducing Agents), saponification of esters and Lewis acid catalysis among others. A representative list of the synthetic reagents offered by Gelest is shown below. Custom synthesis of related materials is a strength of Gelest.
Two additional brochures are available containg further information on Gelests products for synthetic organic chemistry, Silicon-Based Reagents: Protected Organic Molecules and Silicon-Based Synthetic Reagents: Tetrasubstituted Organosilanes.
Some key products;
| SIT8620.0 | Trimethylsilyltrifluoromethanesulfonate |
| SIT8585.0 | Trimethylsilylcyanide |
| SIT8564.0 | Trimethyliodosilane |
| SIT8430.0 | Trimethylbromosilane |
| SIT8330.0 | Triethylsilane |
| SIC2305.0 | Chloromethyltrimethylsilane |
| SIA0555.0 | Allyltrimethylsilane |
| SIC2462.0 | (Cyclohexenyloxy)trimethylsilane |
| HMS-991 | Poly-methylhydrogensiloxane |
| SIE4904.0 | Ethynyltrimethylsilane |
| SIV9250.0 | Vinyltrimethylsilane |
| SIT8571.2 | 2-(Trimethylsiloxy)-1,3-butadiene |
| SIT8362.0 | Trifluoromethyltrimethylsilane |
| SIT8606.3 | 3-Trimethylsilylpropynal |
Silicon-Based Blocking Agents
Silicon-based blocking agents are used for the protection of active protonated species, in particular alcohols, amines, carboxylic acids, and thiols. Typical applications are the protection of these groups to allow further transformations on the molecule without reaction at the protected group and to allow the analysis of high boiling molecules such as acids by converting them to the more volatile silyl ether. Developments over the past several years have centered on the ability to alter the steric and/or electronic nature of the silyl blocking agent to fit the needs of the application in terms of the stability and the ease of deprotection required. For information of the Gelest offering of silicon-based blocking agents see the brochure, Silicon-Based Blocking Agents.
Some key products;
| SIH6110.0 | Hexamethyldisilazane |
| SIB1935.0 | tert-Butyldimethylchlorosilane |
| SIT8250.0 | Triethylchlorosilane |
| SIP6728.0 | Phenyldimethylchlorosilane |
| SIB1846.0 | Bis(trimethylsilyl)acetamide |
| SIB1876.0 | Bis(trimethylsilyl)trifluoroacetamide |
| SID3535.0 | Diisopropyldichlorosilane |
| SID3345.0 | Di-tert-butylsilylbis(trifluoromethane-sulfonate) |
| SIT7273.0 | 1,1,3,3-Tetraisopropyl-1,3-dichlorodisiloxane |
| SIT8384.0 | Triisopropylchlorosilane |
For a more complete listing of Gelest products which are useful as synthetic reagents, click here.
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